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  • New Discovery Drugs Could Block Protein that Ensures Bowel Cancer Growth

    New Discovery Drugs Could Block Protein that Ensures Bowel Cancer Growth

    The scientists at the Institute of Cancer Research, London, recently made a discovery that will open the door to new types of cancer treatment that can control tankyrase more precisely than is currently possible, with fewer side effects. The research revealed crucial structural insights into the elusive but important tankyrase protein, that promote the growth of bowel cancer; as published in the journal Nature. This alone is a groundbreaking discover and the discovery drugs could block this protein that ensures the bowel cancer growth effectively.

    Discovery Drugs  Block Protein that Ensures Bowel Cancer Growth

    This discovery may have other positive implications for the treatment of various cancers, diabetes, inflammatory, cardiac, and neurodegenerative diseases in the future. This was funded by the joint collaboration of the Cancer Research UK and the Institute of Cancer Research (ICR) which was also a charity organisation

    According to biology, Tankyrase is a protein that promotes “Wnt signaling,” which is essential for the body to maintain stem cells and carry out other processes like cell division and development but, when this protein level is left uncontrolled, can promote the growth of bowel cancer and other diseases. it was identified that the same protein Tankyrase also controls other cell functions critical to cancer, such as the maintenance of the ends of chromosomes, the telomeres.

    Discovery Drugs  Block Protein that Ensures Bowel Cancer Growth
    colon (bowel) cancer

    looking at the tankyrase protein; and unlike the PARP1 protein from the same ‘PARP family’, the Tankyrase protein remains poorly understood. Although drugs that inhibit PARP1 have already entered clinical trials and are in use, scientists have yet to fully understand how Tankyrase is activated, how it functions, and how to block it without causing unwanted side effects. But by adopting the Nobel Prize-winning microscopy techniques, the researchers themselves revealed how the Tankyrase protein switches itself on and off by intricately self-assembling into 3D chain-like structures. Their study, published in the journal Nature, lead to the discovery of drugs that can block protein Tankyrase that ensures bowel cancer growth.

    Conclusion

    These researchers from London’s Institute of Cancer Research believe their findings will pave the way for new types of cancer treatment that can control tumor growth more precisely and with fewer side effects than is currently possible. This is good news and gives hope to all of humanity in the fight against cancer and cancerous diseases. If you ever lost someone who suffered from cancer, you would know the loss is unbearable. Leave us a comment if you feel the need to.
    Thank you.

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  • Over The Counter Antibiotics – How Self Prescribed Over The Counter Antibiotics Can Kill You

    Over The Counter Antibiotics – How Self Prescribed Over The Counter Antibiotics Can Kill You

    Over-the-counter (OTC) antibiotics, also known as oral antibiotics, are a class of powerful drugs or medications used to treat bacterial diseases. According to medical news today, antibiotics can’t be used to treat viral infections like coughs, flu, or colds. In this post, we will be discussing how self-prescribed over the counter antibiotics can kill you if not used properly. Self medication is referred to as an area of healthcare whereby the patient takes on a greater degree of responsibility for the treatment of a minor ailment, using pharmaceutical products that are often available without a physician’s or doctor’s prescription.

    See Also

    How Self-Prescribed over the counter antibiotics Can Kill You
    taking med pills

    Classes/Groups of Antibiotics

    ClassExamples
    Penicillinsamoxicillin (Amoxil)
    Macrolidesazithromycin (Zithromax) and erythromycin (Ery-Tab)
    Cephalosporinscephalexin (Keflex) and cefdinir (Omnicef)
    Fluoroquinolonesciprofloxacin (Cipro) and levofloxacin (Levaquin)
    Beta-lactams with increased activityamoxicillin/clavulanate (Augmentin)
    Urinary anti-infectivesnitrofurantoin (Macrobid)
    Lincosamidesclindamycin (Cleocin)
    classes/group of antibiotics courtesy of medicalNews

    When used properly, antibiotics are powerful medications that treat certain infections and save lives. They could either stop bacteria from reproducing or destroy them completely. Naturally, before bacteria can multiply and cause health related symptoms, the body immune system can typically kill them. The body White blood cells (also known as WBCs) attack harmful bacteria — even when symptoms occur, the body immune system can usually cope and fend off the rising infection.

    How Self Prescribed Over The Counter Antibiotics Can Kill You
    body immune system fighting off bacteria

    In some cases, the number of these unwanted, harmful bacteria is excessive, and the body immune system cannot clear them all. This is where antibiotics come to the rescue. According to medical history, the first antibiotic was penicillin. This group of Penicillin-based antibiotics, which includes ampicillin, amoxicillin, and penicillin G, are still available up to today to treat a wide area of infections. There are modern antibiotics that are also available, and this may or may not include the topical antibiotics are readily available in over-the-counter (OTC) creams and ointments.

    How Over the Counter Antibiotics Work

    Over-the-counter antibiotics are divided into two groups based on their functions. Namely;

    Bactericidal over the counter antibiotics, these includes also penicillin-based antibiotics which kills the bacteria. These drugs achieve this function by interfering with either the formation of the bacterial cell wall or its cell contents.
    Bacteriostatic over the counter antibiotics which stops bacteria from multiplying in the body.

    The Emerging Threat

    A growing number of former “prescription-only” medical products are now available over-the-counter in many pharmacies and retail outlets all over the country, thus widening the range and extent of accessibility of these products to the common populace. However, self-prescribed over-the-counter antibiotics remains far from being a safe medical practice, both in theory or in practice, a person who’s not trained shouldn’t do the prescribing, assumption of a symptom’s disease is not the same as medical diagnosis.

    how self-prescribed over -the-counter antibiotics can kill you
    A pharmacist is always there to help

    How Self-Prescribed Over the Counter Antibiotics Can Kill You

    In Nigeria, a typical medical student spends at least 6 years in school before his/her medical practice, some 7 years. A question I do have for self-medication practitioners is: how do you collapse 6 to 7 years of training into one (1) and expect to not make mistakes in your “practice”? Ideally, self medication ought to be for the management of minor or common illnesses, in pursuit of your pharmacist prescription and not one’s assumptions. Some risks involved in self-prescribed over-the-counter antibiotics include:

    Body Antibiotics Resistance

    how self-prescribed over -the-counter antibiotics can kill you
    The body antibiotic resistance effect

    Body antibiotic resistance is an ill-effect case that occurs when germs no longer respond to the antibiotic designed to kill them. The Inappropriate self-prescription of over-the-counter antibiotics is driving up the incidence of antibiotic resistance. Sometimes, this may be prescriptions of the wrong medication , or the wrong dosage which can lead to antibiotic misuse. Over-the-counter antibiotics misuse could also result from who failed to take antibiotics as their doctor prescribed. Some people don’t finish the treatment course and even share with a family member or friend when they discover the relative exhibit the same symptoms. This is not advised, kindly desist from such act.

    Ruining Your Medical “Hope” Through Excessive Unsupervised Use of Over-the-Counter Antibiotics

    how self-prescribed over -the-counter antibiotics can kill you
    CRE

    In the US, the Centers for Disease Control and Prevention (CDC) stated that in the United States alone, around 47 million antibiotic courses are inappropriately prescribed to people, this means they were prescribed antibiotics even when their illness did not require antibiotics. A feared result of this is tha,t some bacteria biologically known as Enterobacterales, can become resistant to carbapenems. These are last-line of defense major class of antibiotics. This is termed carbapenem-resistant Enterobacterales, (CRE). When this happens, there is trouble. Because, Enterobacterales fall under a group of bacteria that can cause pneumonia, meningitis, and other diseases. The famous E.coli (Escherichia coli) is an example of an Enterobacterale. CRE pose a major concern to both medical practitioners and patients in hospitals and other healthcare environments. Medical experts have linked carbapenem resistance in the body to lead to following:

    1. A greater incidence of disease or reoccurrence of disease in the body.
    2. A reduction in the effectiveness of initial antibiotic therapy.
    3. Poorer outcomes in body treatment response.

    Depletion of White Blood Cells (SCFAs) in the Blood

    depletion of white blood cells by antibiotics

    A new study from Case Western Reserve University shows that antibiotics can damage immune cells and worsen oral infections. While carrying out the research, the team of scientist discovered that the antibiotics destroyed the good bacteria, which, consequently, depleted the production of SCFAs and damaged the ability of white blood cells from fighting off fungal infections, such as Candida, in a laboratory setting. the long-term and unsupervised use of antibiotics by a person could really harm the body immune system and its works in fighting viral and other fungal infections and making them harder to treat.

    Autoimmune Disease

    Autoimmune disease
    Psoriasis, a condition marked by thick, scaly patches of skin is a symptom of Autoimmune disease

    Autoimmune disease is when the body’s immune system (natural defense system) can’t tell the difference between your own cells and foreign cells, causing the body to mistakenly attack normal cells. Currently, there are more than 80 types of autoimmune diseases that affect a wide range of body parts. Certain medications like antibiotics, when misused can trigger drug-induced lupus, which is often a more benign form of lupus.

    Medical Case Misdiagnosis

    How Self-Prescribed Medications Can Kill You
    drowning in med pills

    According to the justia article, A misdiagnosis case could be a wrong diagnosis, a missed diagnosis, a delayed diagnosis, or a failure to recognize complications that change or aggravate an existing condition. It is said that sometimes a doctor diagnoses one condition correctly but misdiagnoses another condition or fails to realize that there is a second diagnosis that needs to be made. Consider this: if a medical professional can make this error, how much more can a layperson?

    Excessive/Improper Drug Dosage

    improper drug dosage
    improper drug dosage

    Experts ascribe these to pharmaceutical malpractice, but not when it is done by an unprofessional patient or person. Prescription errors can result in serious injury and death. A person can prescribe an incorrect dose and these errors can result in serious health complications, including allergic reactions, organ damage caused by an overdose, infection, stroke, heart failure, and even death. Even medical doctors and pharmacists must follow strict regulations in order to prevent mistakes. Excessive or improper drug dosage is another way how self-prescribed medications can kill you.

    Unhealthy Extended Drug Usage

    drug abuse

    Long-term drug use can have serious effects of drugs on the body. Chronic abuse can lead to a variety of problems and diseases. This can be the result of unhealthy and extended drug or pill usage. It is advised to always follow the directives of a licensed medical expert.

    Unsafe Drug Interactions.

    How Self-Prescribed Medications can kill you post

    It is very much advised by medical doctors and practitioners in the medical field to restrict patients and people with unverified health symptoms until the underlining causes are well known. The unsafe interaction between yourself and unsupervised drugs can kill you.

    CONCLUSION

    Parts of the body that suffer due to the effects of these risks are often the heart (which is the engine of the body), the kidney, and the liver, Knowing the number of deaths due to drug overdose and abuse is heartbreaking. More on the obvious: how self-prescribed over-the-counter antibiotics can easily lead to death, but thankfully and hopefully, you now understand how this act can kill you after reading this. Leave us a comment if you must.

    References Sources

    1. Ruiz M. E. (2010). Risks of self-medication practices. Current drug safety, 5(4), 315–323.
    2. Hughes, C. M., McElnay, J. C., & Fleming, G. F. (2001). Benefits and risks of self medication. Drug safety, 24(14), 1027–1037.
  • Ask Your Developer PDF Summary Review Book By Jeff Lawson

    Ask Your Developer PDF Summary Review Book By Jeff Lawson

    Ask Your Developer: How to Harness the Power of Software Developers and Win in the 21st Century PDF Summary

    This book looks critically at how Software developers are sought-after, highly paid, and desperately needed to compete in the modern, digital economy. Yet most companies treat them like digital factory workers without really understanding how to unleash their full potential. The author, Ask Your Developer: How to Harness the Power of Software Developers and Win in the 21st Century, Lawson argues that developers are the creative workforce who can solve major business problems and create hit products for customers — not just grind through rote tasks. From Google and Amazon to one-person online software companies — companies that bring software developers in as partners are winning.

    Ask Your Developer: How to Harness the Power of Software Developers and Win in the 21st Century

    From banking and retail to insurance and finance, every industry is turning digital, and every company needs the best software to win the hearts and minds of customers. The landscape has shifted from the classic build vs. buy question, to one of build vs. die. Companies have to get this right to survive. But how do they make this transition?

    Software developers are sought after, highly paid, and desperately needed to compete in the modern, digital economy. Yet most companies treat them like digital factory workers without really understanding how to unleash their full potential. Lawson argues that developers are the creative workforce who can solve major business problems and create hit products for customers—not just grind through rote tasks. From Google and Amazon, to one-person online software companies—companies that bring software developers in as partners are winning. Lawson shows how leaders who build industry changing software products consistently do three things well. First, they understand why software developers matter more than ever. Second, they understand developers and know how to motivate them. And third, they invest in their developers’ success.

    Ask Your Developer: How to Harness the Power of Software Developers and Win in the 21st Century Review

    Top Reviews (Amazon)

    “I’ve been studying culture in companies for a long time, and I’ve talked to hundreds of CEOs. What Jeff and the team have done is one of the most complete and thoughtful approaches to culture I’ve come across yet. Ask Your Developer is a must-read for any leader who is looking for a playbook from one of the most intentional CEOs I’ve interviewed.” — Adam Bryant, coauthor of The CEO Test.

    “Engineering is one of the most creative jobs in the world. Jeff’s Ask Your Developer philosophy is spot on—unleashing the creativity of developers is the key to innovation, no matter what industry you are in.” — Werner Vogels, CTO of Amazon.

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    About  the Author

    Ask Your Developer: How to Harness the Power of Software Developers and Win in the 21st Century
    Jeff Lawson

    Jeff Lawson is a co-founder and CEO at Twilio. He is a serial inventor with over 15 years of entrepreneurial and product experience. Prior to co-founding Twilio, Jeff was Founder & CTO of NineStar, Founding CTO of Stubhub.com and Founder, CEO & CTO of Versity. He was also one of the original product managers for Amazon Web Services. Jeff grew up in the suburbs of Detroit, started his first company in middle school, and earned his BS in Computer Science & Film/Video from University of Michigan. At every business, Jeff identified the fundamental need for a platform for developers and companies to easily build communications-based business solutions.

    Ask Your Developer: How to Harness the Power of Software Developers and Win in the 21st Century. The PDF, Paperback, Hardcover Book Information

    • Publisher ‏ : ‎ Harper Business (January 12, 2021)
    • Language ‏ : ‎ English
    • Hardcover ‏ : ‎ 304 pages
    • ISBN-10 ‏ : ‎ 0063018292
    • ISBN-13 ‏ : ‎ 978-0063018297
    • Item Weight ‏ : ‎ 1.01 pounds
    • Dimensions ‏ : ‎ 6 x 1.01 x 9 inches
    • Best Sellers Rank: #90,844 in Books (Amazon Rakings)

    You can get a copy of Ask Your Developer: How to Harness the Power of Software Developers and Win in the 21st Century in PDF or Paperback from these online stores below.

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  • Girl Online: A User Manual PDF Book Summary

    Girl Online: A User Manual PDF Book Summary

    The unwritten contract of the internet, that a user is what is used, extends from the well-examined issue of data privacy and consent to the very selves women are encouraged to create in order to appear. Invited to self-construct as “girls online,” vloggers, bloggers and influencers sign a devil’s bargain: a platform on the condition they commodify themselves, eternally youthful, cute and responsibility-free, hiding offline domestic, professional and emotional labour while paying for their online presence with “accounts” of personal “experience.”

    Told via the arresting personal narrative of one woman negotiating the (cyber)space between her identities as girl, mother, writer, and commodified online persona, Girl Online is written in a plethora of the online styles, from programming language to the blog/diary, from tweets to lyric prose, taking in selfies, social media, celebrity and Cyberfeminism.

    Girl Online: A User Manual PDF Book Review

    Top Reviews (Amazon)

    “This is theory as user manual for every girl who has misplaced her body, for all who have ever attempted the looking glass life of writing a self onto screen. Walsh does not betray these early desires of screen life even as she elucidates the stark disappointments of its actualization.”—Anne Boyer, author of The Undying

    “A brilliant, timely act of feminist resistance. Joanna Walsh wields language as deliberately as a surgeon her knife. She doesn’t miss a trick, or an opportunity for (s)wordplay. Here as ever she is ‘good to think’ with, a formidable and original theorist for and beyond our online era.”-Lauren Elkin, author of Flaneuse

    “Skilfully captures the fragmentary nature of online existence, the slippery nature of our online selves and their endless interpretations, and both the connections and the alienation that come with it. This is a deep and yet beautifully light meditation on what the internet is doing to our brains.”-Juliet Jacques, author of Trans

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    About Joanna Walsh the Author of Girl Online: A User Manual Book

    Joanna Walsh is a multidisciplinary writer for print, digital and performance. The author of seven books, she also works as a critic, editor and university teacher. She is a UK Arts Foundation fellow, Markievicz Awardee in the Republic of Ireland, and the founder of #readwomen (2014-18), described by the New York Times as ‘a rallying cry for equal treatment for women writers’. She currently runs the pressure group questioning age limits in arts opportunities, @noentry_arts.  Her latest book is Seed published by No Alibis Press. Girl Online will be published in 2022 by Verso Books.

    Girl Online: A User Manual PDF Book, Paperback, Hardcover Book Information

    • Publisher ‏ : ‎ Verso (May 10, 2022)
    • Language ‏ : ‎ English
    • Hardcover ‏ : ‎ 176 pages
    • ISBN-10 ‏ : ‎ 1839765356
    • ISBN-13 ‏ : ‎ 978-1839765353
    • Item Weight ‏ : ‎ 8 ounces
    • Dimensions ‏ : ‎ 5.35 x 0.64 x 8.08 inches

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  • Communicating With Data By Carl Allchin  PDF Summary Review

    Communicating With Data By Carl Allchin PDF Summary Review

    Summary

    This book, Communicating with Data: Making Your Case With Data PDF, emphasized on communication as the key to getting anything done at work. You will need to be clear so your audience can receive, decode, and remember your message. Making use of pre-attentive attributes will help you do this more effectively.

    Communicating with Data: Making Your Case With Data PDF Book
    book cover courtesy of O’Rielly Books

    Data can help you communicate your message more clearly and explore the evidence for and against the points you are making, so you can confirm your ideas with evidence—or adjust them to fit the evidence—before sharing them with others. Data is a fantastic raw resource for powering change in an organization, but all too often the people working in those organizations don’t have the necessary skills to communicate with data effectively. With this practical book, subject matter experts will learn ways to develop strong, persuasive points when presenting data to different groups in their organizations.

    Author Carl Allchin shows anyone how to find data sources and develop data analytics, and teaches those with more data expertise how to visualize data to convey findings to key business leaders more effectively. Once both your business and data experts possess the skills to work with data and interpret its significance, you can deal with questions and challenges in departments across your organization. Learn the fundamental data skills required to work with data. Use data visualization to influence change in your organization. Learn how to apply data techniques to effectively work with data end to end. Understand how to communicate data points clearly and persuasively. Appreciate why different stakeholders often have divergent needs and views.

    Communicating with Data: Making Your Case With Data PDF Summary Review

    Top Reviews (Amazon)

    “An excellent book for anyone interested in data analytics. Really good insight into Tableau and its implementation in the work place, I learnt a lot and would definitely recommend this book”.—James & Soph

    “Simply put, it was clear and well formatted, with little nuggets of wisdom on every page. Would especially recommend Chapter 9 as that actually helps you apply what you have learnt to real-world scenarios. The book was a pleasant read and easy to digest. I think it achieves its purpose in laying the groundwork for anyone (no matter their experience with data) to engage, understand, analyse and then argue with data.”—Suchira Peiris

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     About Carl Allchin the Author of Communicating with Data: Making Your Case With Data PDF Book

    Communicating with Data: Making Your Case With Data PDF Book
    Carl Allchin

    Carl Allchin is a Tableau Zen Master, multiple time Tableau Ambassador and is The “Other” Head Coach at one of the world’s leading data analytics training programs at The Data School in London. After over a decade in Financial Services as a Business Intelligence Analyst and Manager, he supported hundreds of companies through consulting, blogging and teaching on market leading data solutions. Carl is the co-founder of Preppin’ Data, the only weekly Data Preparation challenge on Tableau and other data tools. He published Tableau Prep Up & Running in 2020 through O’Reilly.

    Communicating with Data: Making Your Case With Data PDF Book, Paperback, Hardcover Book Information

    • Publisher ‏ : ‎ O’Reilly Media; 1st edition (October 26, 2021)
    • Language ‏ : ‎ English
    • Paperback ‏ : ‎ 340 pages
    • ISBN-10 ‏ : ‎ 1098101855
    • ISBN-13 ‏ : ‎ 978-1098101855
    • Item Weight ‏ : ‎ 1.2 pounds
    • Dimensions ‏ : ‎ 7 x 0.5 x 9.25 inches
    • Best Sellers Rank: #930,422 in Books (According to Amazon Rankings)

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  • The Little Book of Gold PDF Summary Review Book By Erik Hanberg 

    The Little Book of Gold PDF Summary Review Book By Erik Hanberg 

    The Little Book of Gold Book Summary

    The Little Book of Gold is a practical and step-by-step guide to professional fundraising. It’s dedicated to helping small (and very small) non-profits unlock their fundraising potential. Avoid common pitfalls and get tips on proven methods that work. This book has helped thousands of nonprofits improve their fundraising.

    This short guide helps new Executive Directors, active board chairs, and other key staff in charge of fundraising to learn the basics of professional and sustainable fundraising. Geared specifically for non-profits with small and very small budgets (a few hundred thousand dollars a year down to the smallest budgets).

    The Little Book of Gold: Fundraising for Small (and Very Small) Nonprofits Book Reviews

    Top Reviews (Amazon)

    “OUTSTANDING! I’m going to add my rave review to all the others left here. In fact, I’m using (and attributing) some of his great ideas in a chapter of a book I’ve written–it’s that good. Man, authors don’t usually give such specific advice (and especially, when it’s for a subject that is so small, like a micro-nonprofit). It’s like other authors worry that you’ll steal their ideas, or that nonprofits are all competing with each other and we shouldn’t share ideas. Instead, Erik Hanberg gives specific examples for specific context that totally resonates with anyone who has a board (and any nonprofit is always up for fundraising more money). It’s funny, the way we see the world and the way the world actually works are often two different things, and this book shows how nonprofits don’t just run themselves and exist from the easy goodwill of people’s good hearts, rather, it takes actual work on the part of the employees of a nonprofit to gently steer clients, board members, and donors to do what is best for both themselves and the nonprofit (thus setting up a win-win-win-win…). It’s so easy to talk only in terms of huge nonprofit organizations, like most books do, rather than the realities of a small nonprofit, and I LOVE that this book goes into such detail and such specifics. WELL DONE!!!!”

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    About Erik Hanberg the Author of The Little Book of Gold: Fundraising for Small (and Very Small) Nonprofits

    The Little Book of Gold

    Erik Hanberg has spent more than 20 years working with nonprofits. In addition to serving as the director of two nonprofits, he has served as an Interim ED twice and worked for nonprofits in marketing and fundraising. He has also served on boards and committees for more than a dozen organizations, often in leadership roles, and several times during a capital campaign.

    He is the author of four books for nonprofits, focusing on nonprofit management, fundraising, social media, and board governance, which have collectively sold tens of thousands of copies. They’ve been praised as essential reads for nonprofits by Forbes.com, LinkedIn for Nonprofits, Kirkus Reviews, and thousands of executive directors and board members.

    In addition, he served for more than 12 years in elected office on the board of Metro Parks Tacoma, a junior municipality with an annual operating budget of $50+ million. He lives in Tacoma, Washington, with his wife Mary and two children.

    The Little Book of Gold PDF Book, Paperback, Hardcover Book Information

    • Publisher ‏ : ‎ CreateSpace Independent Publishing Platform (June 26, 2011)
    • Language ‏ : ‎ English
    • Paperback ‏ : ‎ 160 pages
    • ISBN-10 ‏ : ‎ 147520521X
    • ISBN-13 ‏ : ‎ 978-1475205213
    • Item Weight ‏ : ‎ 5.7 ounces
    • Dimensions ‏ : ‎ 5.06 x 0.37 x 7.81 inches
    • Best Sellers Rank: #30,382 in Books (Based on Amazon Books)

    You can get a copy of The Little Book of Gold Book or Paperback from these online stores below.

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  • Doing Agile Right By Darrell K. Rigby, Sarah Elk, and Steve Berez PDF Book Review

    Doing Agile Right By Darrell K. Rigby, Sarah Elk, and Steve Berez PDF Book Review

    Doing Agile Right: Transformation without Chaos PDF Book Summary

    Doing Agile Right: Transformation without Chaos PDF Book

    For decades business leaders have been painfully aware of a huge chasm: They aspire to create nimble, flexible enterprises. But their day-to-day reality is silos, sluggish processes, and stalled innovation. Today, agile is hailed as the essential bridge across this chasm, with the potential to transform a company and catapult it to the head of the pack. This book, Doing Agile Right: Transformation without Chaos PDF summarizes the qualities and how to get The best methods to be agile at work.

    Not so fast. In this clear-eyed, indispensable book, Bain & Company thought leader Darrell Rigby and his colleagues Sarah Elk and Steve Berez provide a much-needed reality check. They dispel the myths and misconceptions that have accompanied agile’s rise to prominence–the idea that it can reshape an organization all at once, for instance, or that it should be used in every function and for all types of work. They illustrate that agile teams can indeed be powerful, making people’s jobs more rewarding and turbocharging innovation, but such results are possible only if the method is fully understood and implemented the right way.

    The key, they argue, is balance. Every organization must optimize and tightly control some of its operations, and at the same time innovate. Agile, done well, enables vigorous innovation without sacrificing the efficiency and reliability essential to traditional operations. The authors break down how agile really works, show what not to do, and explain the crucial importance of scaling agile properly in order to reap its full benefit. They then lay out a road map for leading the transition to a truly agile enterprise.

    Agile isn’t a goal in itself; it’s a means to becoming a high-performance operation. Doing Agile Right is a must-have guide for any company trying to make the transition–or trying to sustain high agility.

    Doing Agile Right: Transformation without Chaos PDF Book Summary Review

    Top Reviews (Amazon)

    “This book helped me to understand the practices and principles needed to do agile in fact. Full of examples and definitions that allow me ground the important concepts when attempting apply an agile philosophy in a organization.”—Carlos Balboa Gomez

    “Historically most companies have innovated product, services, and processes at a glacial, evolutionary pace. No doubt there have been exceptions to this, but I’d argue that many of these were driven by the exceptional genius of individuals or sheer right product/right time luck rather than repeatable processes. In our rapidly changing world, this just won’t cut it. This book provides the blueprint for innovation on steroids, i.e. the ability to adapt and thrive without having to rely on genius or luck. While this book addresses the needs of larger companies, its core tenets are applicable to companies of all sizes: focus on increasing value to customers, prioritize ruthlessly, break complex challenges into tractable constituents, enable dedicated and nimble teams, and ideate/test/learn rapidly.”—Jim K

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    About Darrell K. Rigby, Steve Berez et al the Authors of Doing Agile Right: Transformation without Chaos Book

    Doing Agile Right: Transformation without Chaos PDF Book
    Steve Berez

    Steve Berez is a Boston-based partner at Bain & Company. He is a founder of Bain’s Enterprise Technology practice and was until recently its Americas head. Steve is also a senior leader in our Agile and Healthcare practices. Steve first joined Bain in 1980 and has been with the firm for a total of nearly 30 years. Over the past decade, he has helped dozens of firms across industries and around the world improve the speed, agility, and effectiveness of their technology-based innovation. Steve has driven agile transformations for industry leaders in health, P&C, and life insurance; healthcare delivery; retail banking; consumer and industrial products; retail; transportation; and technology. He also has deep experience in technology strategy and operating model redesign, especially in the context of digital strategy and innovation; software engineering and product management; architecture transformation and complexity reduction, including cloud adoption and core systems modernization; and technology-enabled growth strategy.

    Doing Agile Right: Transformation without Chaos PDF Book
    Darrell Rigby

    Darrell Rigby is a partner in the Boston office of Bain & Company, where he leads the Global Innovation practice. He is a frequent speaker and writer on innovation, agile, and retail and has appeared on CNBC, CNN’s Moneyline, and Bloomberg. His research has been published in Harvard Business Review, the Wall Street JournalBloomberg Businessweek, the Financial Times, and other publications.

    Doing Agile Right: Transformation without Chaos PDF Book
    Sarah Elk

    Sarah is a partner in Bain & Amp; Company’s Chicago office. With nearly 20 years of consulting experience, she is an active leader in Bain’s Results Acceleration and Retail practices. Sarah is passionate about transforming large companies, especially those experiencing technology or business model disruption. She has deep transformation experience at the intersection of organization, agile, performance improvement and change management. Over the course of her career, Sarah has advised business leaders in wide range of industries including retail, technology, healthcare and consumer products, automotive, aerospace defense, and others. She’s worked with multiple Fortune 50 companies. Sarah serves as the Global Solution Leader for Operating Model, Bain’s leading organizational transformation offering. She is a member of Bain’s global governance committee for compensation and promotion. Sarah began her career at Merck & Amp; Co., Inc. after earning her BS in environmental engineering from Northwestern University. She also holds an MBA from Stanford Graduate School of Business.

    Doing Agile Right: Transformation without Chaos PDF Book, Paperback, Hardcover Book Information

    • Publisher ‏ : ‎ Harvard Business Review Press; Illustrated edition (May 26, 2020)
    • Language ‏ : ‎ English
    • Hardcover ‏ : ‎ 256 pages
    • ISBN-10 ‏ : ‎ 163369870X
    • ISBN-13 ‏ : ‎ 978-1633698703
    • Item Weight ‏ : ‎ 1.05 pounds
    • Dimensions ‏ : ‎ 6.4 x 1.1 x 9.3 inches
    • Best Sellers Rank: #47,892 in Books (According to Amazon Rankings)

    You can get a copy of Doing Agile Right: Transformation without Chaos PDF Book or Paperback from these online stores below.

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  • A Living Computer: Designed and Programmed

    A Living Computer: Designed and Programmed

    Introduction

    A Living Computer: Designed and Programmed by scientists from MIT and Technion. The genetic sequence of the plasmid was designed to operate as a basic artificial neural network, or more precisely, a basic computer. The procedure entailed introducing genetic material into a bacterial cell in the form of a plasmid, which is a small DNA molecule that stays apart from the “natural” genome of the bacteria. The study team was able to explicitly construct and program a basic artificial neural network using the many function plasmids that are known to exist freely in nature. This was accomplished by having multiple genes on the plasmid control each other’s activation and deactivation in response to external inputs.

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    Scientists Convert Waste Papers into Battery

    How Can A Computer Be Biological?

    A Living Computer
    A Living Computer

    How can a computer be biological? What does it really mean, a living cell, a circuit?

    In the simplest form and explanation, a computer consists of 0s and 1s, of switches. Operations are performed on these switches: from summing operations to getting the maximal or minimal value between them, etc. And the more advanced operations are built upon the basic ones, which made it possible for a computer to play chess or fly a rocket to the moon without human involvement. Imagine, the possibility of what biological computers can do then, through scientists having designed and programmed a living computer (or perhaps rebellion)?

    A Living Computer 3
    A Living Computer 3

    In “electronic computers,” transistors form the 0/1 switches. Our cells, on the other hand, are also computers, albeit of a different sort. Biologically, the presence or absence of a molecule can act as a switch. Genes are activated, triggered, or suppressed by other genes, forming, modifying, or removing molecules. Synthetic biology is a branch of biology that aims to harness these processes as well as synthesize the switches and program the genes that would allow a bacterial cell to perform complex tasks. Living cells are equipped naturally to sense chemicals and produce organic molecules within its environment. The scientists embarking on the challenge of being able to “computerize” these processes within the cell could have major implications for biomanufacturing and have numerous medical applications.

    A Living Computer 2
    A Living Computer 2

    Conclusion

    The group scientists designed and programmed the living computer were Ph.D students were Luna Rizik and Loai Danial (now doctors) together with Dr. Mouna Habib. They worked under the guidance of Prof. Ramez Daniel in the Faculty of Biomedical Engineering at Technion Institute. And in collaboration with Prof. Ron Weiss from the Synthetic Biology Center, MIT, were wowed and inspired by how artificial neural networks function. They collectively created synthetic computation circuits by combining existing genetic “parts,” or engineered genes, in novel ways, and implemented concepts from neuromorphic.

  • See How Scientists Are Converting Waste Papers into Battery Parts  Used in Smartphones And Electric Vehicles

    See How Scientists Are Converting Waste Papers into Battery Parts Used in Smartphones And Electric Vehicles

    converting waste papers into battery parts  used in smartphones and electric vehicles
    The proposed look like product

    Through a process called carbonization, which converts paper into pure carbon, the Nanyang Technological University (NTU) researchers turned the paper’s fibers into electrodes, which amazingly can be made into rechargeable batteries that power mobile phones, medical equipment, and electric vehicles. In other words, converting waste papers into battery parts used in smartphones and electric vehicles

    carbonised paper
    carbonised paper

    The team started by heating the paper at really high temperatures until it broke down into pure carbon, some water vapour, and a bit of oil that can actually be turned into biofuel. They found that because this carbonisation process happens without oxygen, it releases almost no carbon dioxide. That makes it a much cleaner and greener alternative to burning Kraft paper the usual way, which normally pumps out a lot of greenhouse gases.

    When they put the battery to the test, the carbon anodes made by the research team turned out to be tougher, more flexible, and better performing overall. Lab results showed that these anodes could handle around 1,200 charge and discharge cycles — which is about twice the lifespan of the anodes used in today’s phone batteries. Another impressive thing is how much physical stress they can take. Batteries using the NTU-made anodes can absorb crushing force up to five times better than typical batteries on the market, making them far more durable.

    Scientists Are Converting Waste Papers into Battery Parts  Used in Smartphones And Electric Vehicles
    Some of brains behind the research work

    The team’s method of converting waste papers into battery parts used in smartphones and electric vehicles also adopted the use of less energy-intensive processes and heavy metals compared to current industrial methods of manufacturing battery anodes. Since the anode is worth (10–15)% of the total cost of a lithium-ion battery used in development, It is said that this latest method, which uses low-cost waste material, is expected to also bring down the cost of manufacturing energy sources.

    When asked about this latest discovery by them, the team head replied; “Using waste paper as the raw material to produce battery anodes would also ease our reliance on conventional sources for carbon, such as carbonaceous fillers and carbon-yielding binders, which are mined and later processed with harsh chemicals and machinery.”

    Conclusion

    These team of scientists who are converting waste papers into battery parts used in smartphones and electric vehicles are very brilliant. They have identified a problem; Paper waste, which comprises disposed paper bags cardboard, newspaper, and other paper packaging, accounted for nearly a fifth of the waste generated in Singapore in 2020. Kraft paper bags alone accounts for the majority of Singapore’s paper wastes, These were found to have large environmental footprints when compared to wastes generated by cotton and plastics. Also, due to their greater contribution to global warming when incinerated and the eco-toxicity potential in their production. What a way to save the world!
    So you tell us what you think? Do you think this is an amazing discovery? Can it make the global warming effect reduce in regions like Asia and Singapore to be specific? Leave us a comment in the comment section below.

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  • Everyday Chaos By David Weinberger PDF Summary Review

    Everyday Chaos By David Weinberger PDF Summary Review

    everyday chaos
    everyday chaos

    Designing, testing, and troubleshooting solar power systems require a thorough understanding of how to assess a solar panel’s voltage level. Using a voltage sensor module to interface a solar panel with an Arduino is one of the easiest and most dependable ways to accomplish this. With this project, you can compare daily output fluctuations, study voltage behavior under various sunshine situations, and safeguard your devices by making sure incoming voltage stays within safe tolerances. This project is particularly useful for students, do-it-yourselfers, and renewable energy enthusiasts who wish to learn instrumentation and energy monitoring because it offers real-time visual and serial feedback on your solar input.

    Not so quickly. Sarah Elk and Steve Berez offer a much-needed reality check in this astute and important audiobook. They debunk the myths and fallacies that have followed agile’s expansion, such as the notion that it can completely transform your company or that it ought to be applied to every department and kind of work. They confirm and demonstrate that agile teams can, in fact, change the workplace, increase job satisfaction, and spur innovation—but only if the approach is properly comprehended and applied.

    When implemented properly, agile allows for rapid innovation without compromising the dependability and efficiency necessary for conventional operations. The authors explain how agile actually functions, demonstrate what not to do, and emphasize how vital it is to scale agile correctly to reap its full benefits. After that, they provide a roadmap for spearheading the shift to an enterprise that is really agile.

    Everyday Chaos: Technology, Complexity, and How We’re Thriving in a New World of Possibility

    Top Reviews (Amazon Books)

    “Weinberger’s thought-provoking call to action is a must-read for business leaders pushing the envelope on innovation, for policy makers seeking to protect the public from undue harm, and for the rest of us who are keen to live better lives but mindful of any unintended consequences.”—Aneesh Chopra

    “With classic Weinberger wit and brilliant insight, this book shatters the myth of predictability while delivering grounded, actionable advice for anyone trying to thrive in the everyday chaos that has become our world. A page-turner must-read for everyone.”—Joichi Ito

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    Watch Everyday Chaos: The Book Review

    About David Weinberger; the Author

    David Weinberger
    David Weinberger

    Regarding how the internet affects our lives, our businesses, and most importantly, our ideas, David Weinberger has been a trailblazing thought leader. As a strategic marketing vice president and consultant, an internet advisor to presidential campaigns, an early social networking entrepreneur, a writer-in-residence at Google, a senior researcher at Harvard’s Berkman Klein Center for Internet & Society, a fellow at Harvard’s Shorenstein Center on Media, Politics, and Public Policy, a Franklin Fellow at the US State Department, and a philosophy professor, he has made contributions to a variety of fields, from marketing and libraries to politics and journalism. His books, including the best-selling The Cluetrain Manifesto, have been published in magazines like Harvard Business Review and Wired.

    Everyday Chaos: PDF Book, Paperback, Hardcover Book Information

    • Publisher ‏ : ‎ Harvard Business Review Press (May 14, 2019)
    • Language ‏ : ‎ English
    • Hardcover ‏ : ‎ 256 pages
    • ISBN-10 ‏ : ‎ 1633693953
    • ISBN-13 ‏ : ‎ 978-1633693951
    • Item Weight ‏ : ‎ 1 pounds
    • Dimensions ‏ : ‎ 6.25 x 0.75 x 9.5 inches
    • Best Sellers Rank: #535,449 in Books (Amazon Rankings)

    You can get a copy of Everyday Chaos: Technology, Complexity, and How We’re Thriving in a New World of Possibility PDF Book or Paperback from these online stores below.

    Read More